Accession Number : AD0770937

Title :   Effect of Adrenalectomy of Antibody-Forming Cell Production in Animals with a Delayed Type of Hypersensitivity,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Chebotarev,V. F. ; Valueva,T. K.

Report Date : 12 NOV 1973

Pagination or Media Count : 11

Abstract : The present research has studied the effect of a bilateral adrenalectomy on the formation of cells which form an antibody to the corpuscular antigen (sheep erythrocytes) in guinea pigs with a delayed type of hypersensitivity (HDT) to human serum albumin (HSA). The following conclusions were drawn for guinea pigs which have received an adrenalectomy and have been sensitized by human serum albumin in a complete Freund's adjuvant, participation of the regional lymph nodes is prevalent in antibody formation. The adrenalectomy led to a decrease in the absolute and relative number of antibody-forming cells in the lymph nodes and spleen of the animals. When the adrenals were removed it was obvious that the mechanism which regulates the intensity of proliferation of the lymphoid fiber had been destroyed.

Descriptors :   *Adrenal glands, *Immunology, *Antibodies, Lymphatic system, Spleen, Translations, USSR, Guinea pigs, Experimental data

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE