Accession Number : AD0771108
Title : Photochemical Degradation of Dapsone.
Descriptive Note : Final rept. 1 Jul 72-31 Mar 73,
Corporate Author : PARKE DAVIS AND CO ANN ARBOR MICH
Personal Author(s) : Okerholm,R. A. ; Keeley,F. J. ; Glazko,A. J.
Report Date : 27 JUN 1973
Pagination or Media Count : 22
Abstract : The photochemical degradation of DDS (4,4'-diaminodiphenylsuflane,dapsone) has been shown to be an autocatalytic reaction that is affected by the solvent. Degradation products are tentatively identified by mass spectrometry. None of these compounds were found to be present in the tablets of DDS suspected to contain a toxic agent that might be responsible for the production of agranulocytosis. (Modified author abstract)
Descriptors : *Sulfones, *Photolysis, Mass spectra, Infrared spectra, Ultraviolet radiation, Thin layer chromatography
Subject Categories : Pharmacology
Radiation and Nuclear Chemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE