Accession Number : AD0771108

Title :   Photochemical Degradation of Dapsone.

Descriptive Note : Final rept. 1 Jul 72-31 Mar 73,

Corporate Author : PARKE DAVIS AND CO ANN ARBOR MICH

Personal Author(s) : Okerholm,R. A. ; Keeley,F. J. ; Glazko,A. J.

Report Date : 27 JUN 1973

Pagination or Media Count : 22

Abstract : The photochemical degradation of DDS (4,4'-diaminodiphenylsuflane,dapsone) has been shown to be an autocatalytic reaction that is affected by the solvent. Degradation products are tentatively identified by mass spectrometry. None of these compounds were found to be present in the tablets of DDS suspected to contain a toxic agent that might be responsible for the production of agranulocytosis. (Modified author abstract)

Descriptors :   *Sulfones, *Photolysis, Mass spectra, Infrared spectra, Ultraviolet radiation, Thin layer chromatography

Subject Categories : Pharmacology
      Radiation and Nuclear Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE