Accession Number : AD0771121

Title :   Synthesis of New Antimalarial Drugs (1- and 9-Anthraceneaminoalcohols).

Descriptive Note : Rept. no. 4 (Final) 1 Jun 72-31 May 73,

Corporate Author : INTERNATIONAL MINERALS AND CHEMICAL CORP LIBERTYVILLE ILL

Personal Author(s) : Traxler,James T. ; Moats,Mary J. ; Lira,E. Patrick ; Huffman,Clarence W.

Report Date : JUL 1973

Pagination or Media Count : 52

Abstract : The synthesis of seven anthracene aminoalcohols with one or two additional substituents is described. These compounds include three 1-aminoethanols, two 9-aminoethanols and two 9-aminopropanols, prepared from commercially-available substituted anthraquinones or from 10-chloroanthraldehydes. The synthesis of 1-aminoethanols from substituted benzanthrones was shown capable of producing compounds already available by means of less complex schemes. (Modified author abstract)

Descriptors :   *Antimalarials, *Anthracenes, *Ethanols, *Propanols, *Synthesis(Chemistry), Aldehydes, Chlorine compounds, Amines, Chemical reactions, Halogenated hydrocarbons, Bromine compounds, Iodine compounds

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE