Accession Number : AD0771144

Title :   Monkeys as Hosts of Human Malaria. Experimental Chemotherapy of Human Malaria in New World Monkeys.

Descriptive Note : Final rept. 1 May 65-30 Apr 73,


Personal Author(s) : Young,Martin D. ; Rossan,Richard N. ; Baerg,David C.

Report Date : 01 AUG 1973

Pagination or Media Count : 37

Abstract : It was shown for the first time that human malaria could be grown and maintained in monkeys. The first successful model was plasmodium vivax in Aotus trivirgatus. Passage through the Aotus host enhanced parasite infectivity to Saimiri sciureus, Saguinus geoffroyi, Ateles fusciceps, and Ateles geoffroyi, which previously had been largely refractory. One strain of P. vivax has been maintained by serial passage, trophozoite or sporozoite, for more than 7seven years in Panamanian monkeys. Human malaria in monkeys responds to certain standard drugs similar to that of human malaria in man. Experimental chemotherapy studies of P. vivax in Saimiri and Aotus indicated that chloroquine or pyrimethamine will cure trophozoite induced infections. Sporozoite induced infections relapsed after chloroquine alone. Chloroquine plus primaquine did effect radical cure. Hematologic values were established for Panamanian monkeys. (Modified author abstract)

Descriptors :   *Antimalarials, *Malaria, Chemotherapy, Disease vectors, Drugs, Parasites, Parasitic diseases, Monkeys, Experimental data, Sensitivity, Plasmodium, Primaquine, Hematology

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE