Accession Number : AD0772591

Title :   Effect of Ligands on a Discontinuous Temperature Dependence of the Decarbamylation Reaction of Erythrocyte Acetylcholinesterase,

Corporate Author : BRITISH COLUMBIA UNIV VANCOUVER FACULTY OF PHARMACEUTICAL SCIENCES

Personal Author(s) : Roufogalis,B. D. ; Quist,E. E. ; Wickson,V. M.

Report Date : 17 APR 1973

Pagination or Media Count : 11

Abstract : The report describes the effect of temperature on the decarbamylation of dimethylcarbamylated acetylcholinesterase, and on the activation of this reaction by ligands. Discontinuities in the temperature dependence of the decarbamylation reaction have been observed, and the effect of ligands on these discontinuities is reported. The existence of different temperature and ligand dependent states of the enzyme has been suggested to account for the results. An effect of temperature on the relative concentrations of multiple forms of erythrocyte and serum cholinesterase has also been suggested.

Descriptors :   *Ligands, *Acetylcholinesterase, *Elimination reactions, *Carbamates, Reaction kinetics, Chemical reactions, Temperature, Entropy, Enthalpy, Enzymes, Erythrocytes

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE