Accession Number : AD0773700

Title :   The Movement of Pyridinium Aldoximes across the Red Cell Membrane,

Corporate Author : DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s) : Keen,T. E. B.

Report Date : 21 FEB 1973

Pagination or Media Count : 12

Abstract : The movement of a 2 PAM chloride (2-hydroxyiminomethyl-l-methylpyridinium chloride) across the rabbit red cell membrane was examined. The rate of uptake and efflux of the oxime through the membrane was proportional to the concentration gradient and appeared to be a process of non-assisted diffusion. The uptake was affected by factors such as the pH and ionic strength of the medium which suggested that transport was occurring through ionic pathways in the membrane in a manner similar to that described for inorganic cations. Temperature had a marked effect on the rate of uptake and the energy of activation was high. However, this did not appear to be inconsistent with a process of simple diffusion. Various substances which have been shown to affect selective cation permeability in red cells were examined, but the results did not help in further identifying the diffusion pathways. (Modified author abstract)

Descriptors :   *Erythrocytes, *Membranes(Biology), *Pyridines, *Oximes, Australia, Permeability, Transport properties, Diffusion, pH, Temperature, Ions, Animals, Experimental data

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE