Accession Number : AD0773726

Title :   Serum Creatine Phosphokinase Activity after Intramuscular Injection: The Effect of Dose, Concentration, and Volume.

Descriptive Note : Technical rept. Nov 72-Apr 73,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Sidell,Frederick R. ; Culver,Donald L. ; Kaminskis,Andris

Report Date : JAN 1974

Pagination or Media Count : 15

Abstract : Solutions of two compounds, pralidoxime chloride and sodium chloride, were given intramuscularly to normal human subjects. The ensuing increase in creatine phosphokinase (CPK) activity in the blood was directly related to the concentration and osmolarity of the injected solution when the volume was kept constant and was directly related to the volume when the concentration or osmolarity was constant. This suggests that the diluent may make a significant contribution to increase in CPK seen after intramuscular administration of drugs. (Author)

Descriptors :   *DRUGS, *INTRAMUSCULAR INJECTIONS, ENZYMES, BLOOD SERUM, CHLORIDES, DOSAGE, CONCENTRATION(CHEMISTRY), PERMEABILITY, MEMBRANES(BIOLOGY), DILUENTS, OSMOTIC PRESSURE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE