Accession Number : AD0773905

Title :   Phospholipid Changes during Single and Repeated Anaphylactic Shocks in Guinea Pigs,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Valkova,B.

Report Date : 08 JAN 1974

Pagination or Media Count : 10

Abstract : In the chain of processes determining the initiation and the course of anaphylactic shock, the activation of individual proteolytic enzymes (G. Ungar) and the activation of poorly differentiated enzymatic systems, in particular lecithinase, have been demonstrated. The activation of lecithinase leads to the destruction of the basophil tissue with subsequent release of histamine and other biologically active compounds. On the basis of these facts, single studies of the lipid metabolism during anaphylaxis have been made. The purpose of this work is to compare the phospholipid changes in single and in repeated anaphylactic shocks for a long period of time. The conditions of the chronic experiment were chosen so as to best resemble the changes occurring during bronchial asthma in men.

Descriptors :   *Phospholipids, *Anaphylaxis, Lipids, Metabolism, Enzymes, Lung, Respiratory system, Bulgaria, Translations, Guinea pigs, Experimental data

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE