Accession Number : AD0774938

Title :   Burn Wound Therapy.

Descriptive Note : Final rept. 1 Apr-31 Dec 73,

Corporate Author : HARVARD MEDICAL SCHOOL BOSTON MASS DEPT OF SURGERY

Personal Author(s) : Dressler,Donald P. ; Blackburn,George L.

Report Date : 01 FEB 1974

Pagination or Media Count : 39

Abstract : There is no demonstrable advantage in the burn rat model to therapy consisting of a single application of liquid nitrogen to the burn wound. No significant alteration in the results was found in both the seeded and non-seeded burn controls in the mortality, eschar separation, insensible water loss, bacteriologic, histologic and biochemical studies. It was concluded therefore, that although the single application of liquid nitrogen may possibly be of some help in the clinical situation, on the basis of these laboratory studies and our clinical experience, the authors believe that the increased risk of sepsis and the possibility of further epidermal damage, particularly in the deep second degree injury, would outweigh any advantage. (Modified author abstract)

Descriptors :   *Burns(Injuries), Pathology, Therapy, Physiology, Surgery, Wounds and injuries, Microorganisms, Laboratory animals, Chemotherapy, Rats, Models, Histology, Experimental data

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE