Accession Number : AD0775307

Title :   Multiple Schlerosis: A New Hypothesis,

Corporate Author : CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MASS DEPT OF NEUROLOGY

Personal Author(s) : Mickel,Hubert S.

Report Date : 08 MAY 1974

Pagination or Media Count : 16

Abstract : As a result of enteric infection, peroxidized arachidonic acid and other fatty acids might be absorbed from the intestine, where there is customarily little absorption. Absorbed peroxidized arachidonic acid adsorbed onto to platelet surfaces would be transported throughout the body. The effect of peroxidized arachidonic acid on human platelets has been demonstrated as a potent aggregating agent. In the post-capillary venule in white matter, as well as elsewhere, platelets would aggregate and allow the passage of lipid peroxide to the surrounding white matter. Attack of the lipid peroxide on sulfhydryl groups would result in denaturation of proteins and provide an antigen for the production of an autoimmune response. (Author)

Descriptors :   *Nervous system diseases, Paralysis, Etiology, Pathology, Blood platelets, Lipids, Oxidation, Fatty acids, Virus diseases, Autoimmunization, Immunology, Gastrointestinal diseases

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE