Accession Number : AD0775339

Title :   Genetic Control of the Tendency to Tolerance Circumvention,

Corporate Author : DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s) : St. Rose,J. E. M. ; Cinader,B.

Report Date : 25 APR 1973

Pagination or Media Count : 7

Abstract : Random bred rabbits were injected with human serum albumin (HA) at birth to induce tolerance to HA. Tolerant animals were then immunized with a p-azobenzenesulfonic acid derivative of human albumin (HA-D31). A proportion of these animals, 42%, (27/64) responded with the production of antibody to HA-D31 (TCR-responders). Matings were carried out between TCR-responders and between TCR-nonresponders, and the offspring were subjected to the same procedures as their parents. Selective breeding of TCR-responders produced 70% (12/17) responders after two generations. Selective breeding of TCR-nonresponders produced only TCR-nonresponders after the third generation. Fourth generation offspring of TCR-nonresponders, which were not injected with HA at birth, produced an antibody response to HA-D31. The genetic control of responsiveness to HA-D31 in HA-tolerant rabbits is polygenic and autosomal. (Modified author abstract)

Descriptors :   *Immunology, *Genetics, Antigen antibody reactions, Rabbits, Experimental data, Canada

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE