Accession Number : AD0775475

Title :   Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.

Descriptive Note : Final technical rept. Dec 72-Nov 73,

Corporate Author : ISTITUTO DI EMATOLOGIA GENOA (ITALY)

Personal Author(s) : Salvidio,E. ; Gaetani,G. ; Ajmar,F. ; Ravazzolo,R. ; Ghio,R.

Report Date : DEC 1973

Pagination or Media Count : 15

Abstract : A sensitive in vitro method has been set up which measures the stimulation of the hexose monophosphate shunt (HMS) in normal and glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells. It has been used to measure and compare the stimulation produced by methylene blue, primaquine, sulphalene, fanasil, DFD and the experimental drug WZB 08271. These drugs stimulate the HMS in normal red cells but are unable to do so in G6PD deficient cells. In view of these results it is presumed that drugs capable of stimulating the HMS in normal red cells would cause lysis of G6PD deficient red cells in vivo. This prediction has been confirmed in studies using chromium labelled G6PD-deficient red cells in vivo. (Author)

Descriptors :   *Antimalarials, *Drugs, Erythrocytes, Deficiencies, Enzymes, Hexoses, Hemolysis, Biochemistry, Italy

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE