Accession Number : AD0775796

Title :   A Comparative Study of Human and Monkey ('Macaca irus') Fibrinogen Degradation Products.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Poskitt,Thomas R. ; Fortwengler,H. Philip , Jr. ; Roth,Gerald J. ; Eaton,James A. , Jr

Report Date : 27 SEP 1973

Pagination or Media Count : 15

Abstract : Immunochemical, physical, and anticoagulant properties of human and monkey (Macaca irus) fibrinogen degradation products (FDPs) were compared by immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDPs derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans. (Author)

Descriptors :   *Fibrinogen, Blood proteins, Immunology, Degradation, Physical properties, Anticoagulants, Humans, Monkeys

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE