Accession Number : AD0776195

Title :   Sequential Search of Optimal Dosages for Non-Interactive Repetitive Models: I. Unknown Intercepts.

Descriptive Note : Technical rept.,

Corporate Author : CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS

Report Date : 15 MAR 1974

Pagination or Media Count : 13

Abstract : The problem of the sequential determination of optimal dosages is, studied for a non-interactive repetitive model. Each patient has its own optimal dosage. The dosage-logtoxicity regression lines are linear. Those of different patients have different unknown intercepts (slopes known). Bayes sequential adaptive procedures of search developed. (Author)

Descriptors :   *Dosage, *Optimization, Chemotherapy, Search theory, Random variables, Distribution functions, Regression analysis, Bayes theorem, Sequential analysis

Subject Categories : Radiobiology
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE