Accession Number : AD0776648

Title :   Interaction of Rare Gases with Model Membranes and its Implication for Narcosis.

Descriptive Note : Final rept. 1 Jun 70-31 Aug 73,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD DEPT OF CHEMISTRY

Personal Author(s) : Koski,Walter S.

Report Date : 22 MAR 1974

Pagination or Media Count : 63

Abstract : A study is reported of the interaction of rare gases and other anesthetic agents with membranes and the findings are examined for their implication on narcosis. The report is divided into four categories: The development of an appropriate bioassay method for determining the anesthetic potency of the inert gases as well as other volatile anesthetics; the physicochemical aspects of the action of general anesthetics agents is examined on a molecular basis; some very preliminary observations on the effect of inert gases on ion transport in frog sartorius muscle; the non-applicability of the widely used INDO method to the calculation of the intermolecular energies that play such an important role in anesthesia as well as many other biological processes.

Descriptors :   *Rare gases, *Anesthetics, *Biomolecules, Membranes(Biology), Biophysics, Ion exchange, Models, Bioassay, Biochemistry, Physiology, Hyperbaric conditions, Shrimp

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE