Accession Number : AD0776662

Title :   Study of the Immunochemistry and Immunizing Properties of a Unique Antigenic Material Isolated from the Staphylococci.

Descriptive Note : Final rept. 1 Mar 71-31 Dec 73,


Personal Author(s) : Ekstedt,Richard D.

Report Date : 29 MAR 1974

Pagination or Media Count : 28

Abstract : The report summarizes studies done on the immunochemistry and immunizing properties of a polysaccharide slime layer material synthesized by strains of S. aureus when cultured under appropriate conditions on a modified Staphylococcus 110 medium. It was found that the polysaccharide was composed of a polymer of galactose and galacturonic acid, but also contained significant amounts of glycine, proline, glutamic acid,and alanine. Neither active nor passive immunization studies with a number of recently isolated or laboratory strains of S. aureus consistently demonstrated any protection inducing antigenic properties in slime layer against experimental challenge of mice with the Smith, diffuse strain of S. aureus or with homologous non-Smith strains. It was also demonstrated that the antigen(s) present in slime layer material adsorbed spontaneously to erythrocytes from several species and sensitized them for passive hemagglutination in the presence of staphylococcal antibody. (Modified author abstract)

Descriptors :   *Staphylococcus aureus, *Immunology, Antigens, Immunity, Antigen antibody reactions, Serology, Agglutinins, Polysaccharides, Chemical properties, Mice, Experimental data

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE