Accession Number : AD0776755

Title :   Study of Neomycin Preparations by the Countercurrent Distribution Method,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Sannikov,V. A.

Report Date : 11 MAR 1974

Pagination or Media Count : 7

Abstract : The method of countercurrent distribution is widely used in analytical practice and assumes distribution of substances between two liquid phases. In this work it was used to determine the components in neomycin antibiotics: colimycin, mycerin, and framycetin. It is known that neomycin represents a hydrophilic base which dissolves well in water and is virtually insoluble in many organic solvents. In order to change the hydrophilic properties of this antibiotic use was made of aryl or alkyl sulfonic acids which with neomycin form products of an apparently complex nature. These products are quite stable in solution.

Descriptors :   *Neomycins, *Antibiotics, Chemical analysis, Chemotherapeutic agents, Identification, Purification, USSR, Translations

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE