Accession Number : AD0776893

Title :   Protonation Reaction as a Method for Identification of Heptaene Antibiotics of the Candicidin Group,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Bershtein,I. Ya.

Report Date : 11 MAR 1974

Pagination or Media Count : 6

Abstract : The identification of aromatic heptaene antibiotics of the candicidin group (trichomycin, levorin, candicidin) has been hampered due to the complete coincidence of the usual physicochemical parameters for these antibiotics. They can be distinguished only by extremely complex analysis methods - counterflow distribution, IR and NMR spectra. In seeking a fairly simple method of estabilishing the authenticity of these antibiotics for mass analysis, the authors noticed that all of them form intensively blue solutions in concentrated sulfuric acid. This is evidently explained by their protonation along the haptaene chain with the formation of the carbonic ion II with a positive charge. Preliminary experiments showed that the protonation reaction is suitable for identification of heptaene antibiotics and apparently is characteristic for the majority of polyene antibiotics.

Descriptors :   *Antibiotics, Addition reactions, Protons, Chemical analysis, Physical properties, Identification, USSR, Translations, Drugs

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE