Accession Number : AD0776918

Title :   Physicochemical Methods of Analyzing Hygromycin B,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Bashkovich,A. P. ; Redi,N. S.

Report Date : 26 MAR 1974

Pagination or Media Count : 6

Abstract : Hygromycin B is an antibiotic which possesses anthelmintic properties; it is produced simultaneously with another antibiotic - hygromycin A - by a strain of Str. hygroscopicus. Hygromycin B contains two groups of a basic character. In connection with this the separation of hygromycin B from the accompanying antibiotic can be carried out by sorption on cationites with subsequent desorption with aqueous or water-acetone solutions of ammonia or by dilute solutions of acids. To provide rapid evaluation of antibiotic concentration in solutions, the authors made an effort to develop adsorption-spectrophotometric methods of analyzing the antibiotic, working on the basis of the physicochemical properties of the antibiotic and its structural peculiarities.

Descriptors :   *Anthelmintics, *Antibiotics, Chemotherapeutic agents, Solvent extraction, Chemical analysis, Physical properties, Purification, Bacteria, USSR, Translations

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE