Accession Number : AD0777003

Title :   Stimulation of Protein Synthesis in Normal and Tumor Cells by Agents Modifying the Cell Surface,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s) : Artamonova,V. A. ; Kiselev,L. K. ; Tikhonova,Z. N. ; Shlevyagin,V. Ya. ; Kiseleva,L. G.

Report Date : 1974

Pagination or Media Count : 17

Abstract : The report discusses the study of the intensity of protein synthesis in cells of various origin (both malignant and normal), by the inclusion of C14 of amino acids in the acid-insoluble fraction. For agents modifying the cell surface, several substances having little in common were chosen: inactivated Sendai parainfluenza virus (complex nucleoprotein), DEAE-dextran (polysaccharide containing diethylaminoethyl groups with postive charge), dimethylsulfoxide (organic solvent of simple structure-DMSO), and Tween 80 (incomplete detergent containing hydrocarbon chains). As a result of tests run in the present study, it has been established that the agents used raise the rate of protein synthesis in intact cells.

Descriptors :   *Neoplasms, Proteins, In vivo analysis, Cells(Biology), Biosynthesis, USSR, Translations, Membranes(Biology), Amino acids, Stimulation(Physiology), Viruses, Chemicals

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE