Accession Number : AD0777004

Title :   Studies on Pulmonary Oxygen Poisoning and the Role of Oxygen in Repair Processes.

Descriptive Note : Final technical rept.,

Corporate Author : TURKU UNIV (FINLAND) DEPT OF MEDICAL CHEMISTRY

Personal Author(s) : Niinikoski,Juha

Report Date : NOV 1973

Pagination or Media Count : 58

Abstract : Pulmonary oxygen toxicity, a progressive process which destroys cells in the lung, is ultimately fatal if exposure to increased oxygen pressure continues and can be stopped only by reduction of the inspired pO2 to a non-toxic level. Prolonged exposure to high oxygen tensions and resulting derangement of cellular metabolism throughout the lung lead to progressive impairment of one aspect of pulmonary function after another until the lung is no longer able to sustain an adequate gas exchange with the blood. The significance of adequate oxygen supply in healing tissues has been demonstrated both experimentally and by clinical proofs. Repair of fractures responds to changes in arterial oxygen tension, and the main targets of oxygen in healing bone appear to be the synthesis of collagen and mineralization.

Descriptors :   *Oxygen, Therapy, Lung, Respiratory system, Pathology, Toxicity, Collagen, Healing, Tissues(Biology), Bones, Surgery, Physiology, Finland

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE