Accession Number : AD0777016

Title :   Effects of 5-Fluorouracil on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-Wound Lesion.

Descriptive Note : Annual rept. no. 1, 1 Jun 72-31 May 73,

Corporate Author : NORTHERN ARIZONA UNIV FLAGSTAFF DEPT OF BIOLOGICAL SCIENCE

Personal Author(s) : Grim,John Norman

Report Date : 23 JAN 1974

Pagination or Media Count : 10

Abstract : Lesions of both groups contained moderate densities of astrocytes. The average density in the 5-FU treated group was less than that of the controls by 12.6% at the 95% confidence level; therefore, the chemotherapy reduced the cell density. Cell migration into the lesion is a possible explanation for the relatively small reduction in astrocyte density. With the present state of knowledge, 5-FU chemotherapy is not warranted to facilitate CNS 'nerve' regeneration. (Modified author abstract)

Descriptors :   *Spinal cord, *Nerve cells, *Central nervous system, *Regeneration(Physiology), Fluorine compounds, Chemotherapy, Nerves, Wounds and injuries, Rats, Experimental data, Neurology

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE