Accession Number : AD0777466

Title :   Mechanisms of Oxygen Toxicity at the Cellular Level.

Descriptive Note : Annual rept. 1 Jan-31 Dec 73,

Corporate Author : MISSOURI UNIV COLUMBIA

Personal Author(s) : Brown,Olen R.

Report Date : JAN 1974

Pagination or Media Count : 36

Abstract : The most significant finding has been the demonstration that even five minute exposures to oxygen at four atmospheres produces a severe, but reversible (upon removal from hyperoxia), inhibition of active transport of glucose, using Escherichia coli as a model cell system. Experimental data is so far consistent with the current operating theory that a site in membrane transport is the primary target in acute oxygen toxicity at the cell level. The inhibition of transport apparently is not due to lack of energy (ATP) for transport, nor to oxidative destruction of the membrane, but the true mechanism is unknown. (Modified author abstract)

Descriptors :   *Hyperbaric conditions, Cells(Biology), Transport properties, Membranes(Biology), Fatty acids, Biosynthesis, Enzymes, Physiology, Biochemistry, Oxygen, Toxicity

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE