Accession Number : AD0777899

Title :   PH Effects on Chloroform Extraction of Drugs of Abuse from Urine.

Descriptive Note : Final rept. Aug-Dec 73,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Merritt,James H. ; Sulkowski,Thomas S. ; Lathrop,George D.

Report Date : MAR 1974

Pagination or Media Count : 6

Abstract : The optimum pH for the single chloroform extraction of barbiturates and amphetamines was determined using radiolabelled drugs. Over the pH range 7.5-8.5, extraction of phenobarbital and amphetamine from urine into chloroform varied widely. The extraction of pentobarbital was much less affected by pH. For a single extraction of these drugs into chloroform, pH should be maintained at 8.0-8.2. (Author)

Descriptors :   *Drugs, *Barbiturates, *Amphetamines, *Solvent extraction, pH factor, Chloroform, Chemical analysis, Urine, Drug abuse, Detection

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE