Accession Number : AD0778159

Title :   Screening for Selective Inhibitors of the Phosphonylation of Acetylcholinesterase.

Descriptive Note : Technical rept.,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Steinberg,George M. ; Cramer,Joyce

Report Date : APR 1974

Pagination or Media Count : 9

Abstract : With the object of finding prophylactic drugs to prevent organophosphorus anticholinesterase poisoning, six unsymmetrical bisquaternary compounds containing large lipophilic groups were compared for their ability to inhibit phenylacetate hydrolysis and the reaction of the enzyme with GD. These compounds failed to provide favorable differences; the principle, however, is important. Acetylcholinesterase is an allosteric enzyme. In time, allosteric perturbers should be found which will provide the means for selective control of the enzyme's biologically critical reactions. (Author)

Descriptors :   *ACETYLCHOLINESTERASE, *ENZYME INHIBITORS, HYDROLYSIS, CHEMICAL REACTIONS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE