Accession Number : AD0778681

Title :   Selection of the Griseofulvin Producer 'Pen. nigricans Thom' through the Action of Mutagenic Factors,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Kommunarskaya,A. D.

Report Date : 15 APR 1974

Pagination or Media Count : 6

Abstract : Through the use of mutagenic factors and selection a new variant of the griseofulvin producer was obtained - the strain 52-beige. On the average its activity on a medium with corn flour exceeds the activity of the initial strain 964 by 25%. The span of variability in terms of antibiotic formation is somewhat less for sublines of the 52-beige strain than the span of variability of strain 964; the corresponding coefficients of variability are 44% and 52%. A total of 150 sublines of the 52-beige strain were studied in depth conditions on a medium with corn flour. Considerable variability was noted with respect to antibiotic formation.

Descriptors :   *Antibiotics, *Griseofulvin, *Fungicides, Mutagens, Cultures(Biology), Fungi, Dosage, Gamma rays, USSR, Translations, Corn, Flour, Ultraviolet radiation, Culture media, Drugs

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE