Accession Number : AD0778723

Title :   Alterations in Oxygen Transport in Stored Canine Blood from Donors having Undergone Chronic Exercise.

Descriptive Note : Progress rept.,


Personal Author(s) : Shields,C. E. ; Moore,S. B. ; Bratton,J. F. ; Brooks,D. E. ; O'Maley,L. M.

Report Date : 28 NOV 1973

Pagination or Media Count : 12

Abstract : Blood was drawn into acid citrate dextrose units, stored over a six week period and analyzed for changes in oxygen dissociation P50 point, pH, 2,3 diphosphoglycerate and adenosine triphosphate levels. One group of units was drawn from sedentary animals. The other two groups were obtained from animals that had been exercised chronically for a short period (Phase I) or after an additional longer exercise period (Phase II). Significant increases in the 2,3 diphosphoglycerate levels were observed in units from Phase I with a greater increase noted in those from Phase II. Despite the general decline of all levels during the long storage period, the exercise group consistently showed definite higher levels over the controls. Similarly, a decrease in P50 value was seen in all units during storage; however, those from the exercised subjects tend to show higher initial levels. Changes in pH and adenosine triphosphate were similar to those obtained from previous studies with no significant differences observed between exercised and nonexercised groups. (Modified author abstract)

Descriptors :   *Blood preservation, *Exercise(Physiology), *Blood transfusion, *Blood donors, Transportable, Oxygen, Dogs, Blood banks, pH factor, Hypoxia, Physiological effects, Adenosine phosphates, Experimental data

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE