Accession Number : AD0778728

Title :   A Collected Bibliography of Clinical Advances in Sickle Cell Disease Based on the Murayama Molecular Hypothesis (Updated from 16 November 1972).

Descriptive Note : Progress rept.,


Personal Author(s) : Nalbandian,Robert M. ; Camp,Frank R. , Jr

Report Date : 17 JAN 1974

Pagination or Media Count : 20

Abstract : The Murayama hypothesis for the molecular events involved in the interior of a sickling hemoglobin red cell is based in part on his construction of a precision scale model of the hemoglobin S molecule. Murayama, drawing in part upon the molecular investigations of others, such as Pauling, Braunitzer, Konigsberg, Muirhead, Perutz, and Ingram, has in effect provided us with a molecular definition of disease and a description of molecular interaction which has pathogenetic significance in sickle cell disease. This is the first time any disease has been understood in such terms at the molecular level in medicine. The cited references in this bibliography are all directly derived from the Murayama hypothesis either by deduction or inference.

Descriptors :   *Anemias, *Bibliographies, Blood diseases, Molecular biology, Sickle cells, Therapy, Diagnosis(Medicine), Hematology, Hemoglobin, Medical research

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE