Accession Number : AD0778730

Title :   Oxygen Transport Changes in Canine Subjects Transfused with Stored Blood from Chronically Anemic Donors.

Descriptive Note : Progress rept.,


Personal Author(s) : Shields,Charles E. ; Zegna,Angelo I. ; Meixner,David E. ; Phillips,Garry C.

Report Date : 07 FEB 1974

Pagination or Media Count : 12

Abstract : Blood from the anemic dogs was stored for 14, 28 or 42 days and compared to normal stored blood. A decrease in oxygen dissociation P50 point, 2,3 diphosphoglycerate, and adenosine triphosphate occurred with storage in both sets. 2,3 diphosphoglycerate levels were slightly higher initially in anemic units and remained higher than those of the controls during storage. Transfusion of the stored blood had minimal effect on the recipient, probably because of the volume (40 ml) used. A small, but significant, increase in the P50 was observed immediately after transfusion of the anemic blood. Adenosine triphosphate levels increased significantly and remained high 24 hr after transfusion. Red cell survival decreased with storage for both normal and anemic stored units, but the decrease was not as marked with the anemic units, suggesting that the population distribution of these may have been different as compared to those of the normal units. (Modified author abstract)

Descriptors :   *Blood preservation, *Anemias, *Blood donors, *Blood transfusion, Adenosine phosphates, Blood banks, Oxygen, Transportable, Dogs, Blood transfusion, Erythrocytes, Metabolism, Hemolysis, Experimental data

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE