Accession Number : AD0779143

Title :   Hemolysis under Acid Stress in Stored Canine Red Cells from Anemic and Exercised Subjects.

Descriptive Note : Progress rept.,


Personal Author(s) : Shields,Charles E. ; Zegna,Angelo I. ; DeVenuto,Frank ; Wilson,Sarah M.

Report Date : 26 NOV 1973

Pagination or Media Count : 13

Abstract : Exposure of canine red cells to acid stress was carried out using samples drawn from special experimental subjects. Differences between samples based on storage time or between anemic and exercised animals were not found to be significant. There was a slight increase in osmotic fragility with storage but was less rapid for the red cells from the exercised animals. The changes in hemolysis for samples from anemic or exercised animals were in contrast to previous findings from normal dogs. The ability of these red cells to tolerate the acid stress--although having similar pH findings--would imply a change in the red cell membrane or metabolism to balance the acid stress. Since the osmotic fragility was slightly greater in cells from the exercised group, but the methylene blue uptake was better, the change may have been more related to altered cell metabolism rather than the membrane. (Modified author abstract)

Descriptors :   *Hemolysis, *pH factor, *Stress(Physiology), *Blood preservation, Erythrocytes, Dogs, Acids, Exercise(Physiology), Anemias, Metabolism, Blood banks, Cells(Biology), Membranes(Biology), Sensitivity

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE