Accession Number : AD0779147

Title :   Oxygen Transport Changes During Replacement with Stored Blood in a Hemorrhagic Canine Model.

Descriptive Note : Progress rept.,


Personal Author(s) : Shields,Charles E. ; Meixner,David E. ; Bratton,Joseph F. ; Brooks,Daniel E. ; Phillips,Garry C.

Report Date : 04 MAR 1974

Pagination or Media Count : 12

Abstract : Healthy beagles were bled 30% of their estimated blood volume and maintained in this low blood pressure state for a finite period and then transfused with blood stored for 14, 28 or 42 days. Blood samples from the stored units and before and after transfusion were analyzed for oxygen function changes indicate by shifts in P50, 2, 3 diphosphoglycerate levels, as well as testing for adenosine triphosphate (ATP) and plasma hemoglobin levels. Decreases in P50, DPG and ATP, with an elevation of the plasma hemoglobin, were readily observed with stored blood. Despite these lower levels, a minimal effect was detected in the recipient which usually cleared in two hr. These findings suggest there is physiological accommodation of bank blood with poor oxygen function indicators without adverse effect on the recipient when considering that 30% or less blood volume was lost. (Author)

Descriptors :   *Blood transfusion, Experimental data, Dogs, Oxygen, Transportable, Blood preservation, Blood banks, Hemoglobin, Blood pressure, Physiological effects, Hemorrhage

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE