Accession Number : AD0779275

Title :   Investigation of the Effect of Furacilin (Nitrofurazone) and Certain Antibiotics on the Development of 'Pen. nigricans Thom' and Extraneous Microflora in the Process of Griseofulvin Biosynthesis,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Kozlova,T. V. ; Mustafova,N. N.

Report Date : 15 APR 1974

Pagination or Media Count : 8

Abstract : In the entire process of production of biologicals the greatest attention is paid to measures which make it possible to carry out the technological process under sterile conditions. Laboratory experiments were carried out to determine the effect of various antibiotics and of furacilin (nitrofurazone) on the development of the griseofulvin producer and foreign microflora. The following antibiotics can be used for sterile fermentation of penicullium nigricans: levomycetin (10, 20, 40 units/mz), the potassium salt of penicillin (40, 60 units/mz), streptomycin (50 units/mz), and a mixture of penicillin and streptomycin, 50 units/mz each.

Descriptors :   *Griseofulvin, *Antibiotics, Biosynthesis, Fungi, Fungicides, Fermentation, USSR, Translations

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE