Accession Number : AD0779500

Title :   Lymphocytes and Yellow Fever. II. Mechanisms Involved in the Transient Virus Refractory State Following Vaccination in Man with the 17-D Strain of Yellow Fever Virus.

Descriptive Note : Final comprehensive rept. 1 Aug 70-31 Dec 71,

Corporate Author : JEFFERSON MEDICAL COLL PHILADELPHIA PA DEPT OF MICROBIOLOGY

Personal Author(s) : Wheelock,E. Frederick

Report Date : 30 APR 1974

Pagination or Media Count : 43

Abstract : Human lymphocytes stimulated with PHA are capable of supporting the replication of many viruses, including 17-D, in vitro. Lymphocytes removed from 17-D virus vaccinated human volunteers, 7-11 days following immunization, failed to support 17-D virus replication in vitro; by day 25, lymphocytes from most vaccines had regained completely their capacity to replicate 17-D virus. The results of our studies suggest that the 17-D virus refractory state may be attributable to the release of cytotoxic substances by certain lymphocytes in culture which in turn affect the ability of other cells to support virus replication. The substantiation of these results would suggest a similar mechanism for the control of viral infections by lymphocytes in vivo. (Author)

Descriptors :   *Immunity, *Yellow fever, *Lymphocytes, *Vaccines, *Interferon, Leukocytes, In vivo analysis, Virus diseases, Yellow fever virus, Immunoglobulins, Infectious diseases, Immunization

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE