Accession Number : AD0779540

Title :   Aldehyde Treatment of Cyanide Poisoning in Mice

Descriptive Note : Technical rept. Sep-Oct 1973

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Steinberg, George M ; Thomas, Norman C

PDF Url : AD0779540

Report Date : Apr 1974

Pagination or Media Count : 11

Abstract : Eight aldehydes have been tested as therapeutic compounds for cyanide poisoning in mice. The most effective are glyoxal trimer and glyceraldehyde. These increase the LD50 2.5 to 3 times. No correlation was found between activation of the carbonyl group resulting from nearby electron-withdrawing substituents and therapeutic value.

Descriptors :   *ALDEHYDES, *CYANIDES, BIOASSAY, CHEMOTHERAPY, DOSAGE, DRUGS, IN VIVO ANALYSIS, LABORATORY ANIMALS, MICE, PARENTERAL INFUSIONS, PHARMACOLOGY, POISONING, PYRUVIC ACID, TOXICOLOGY

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE