Accession Number : AD0779540

Title :   Aldehyde Treatment of Cyanide Poisoning in Mice.

Descriptive Note : Technical rept. Sep-Oct 73,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Steinberg,George M. ; Thomas,Norman C.

Report Date : APR 1974

Pagination or Media Count : 11

Abstract : Eight aldehydes have been tested as therapeutic compounds for cyanide poisoning in mice. The most effective are glyoxal trimer and glyceraldehyde. These increase the LD50 2.5 to 3 times. No correlation was found between activation of the carbonyl group resulting from nearby electron-withdrawing substituents and therapeutic value. (Author)

Descriptors :   *ALDEHYDES, *CYANIDES, LABORATORY ANIMALS, MICE, CHEMOTHERAPY, POISONING, DOSAGE, IN VIVO ANALYSIS, PARENTERAL INFUSIONS, TOXICOLOGY, DRUGS, PHARMACOLOGY, BIOASSAY, PYRUVIC ACID

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE