Accession Number : AD0779656

Title :   Determination of Component Ratios in Industrial Preparations of Neomycin by the Chromatographic Method,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Sannikov,V. A.

Report Date : 16 APR 1974

Pagination or Media Count : 4

Abstract : The antibiotic neomycin consists of two isomeric components, B and C. It has been shown that the neomycinic antibiotics colimycin (colistin), mycerin, and framycin also consist of no less than two antibiotically active components. The authors used a developed method of chromatographic comparison of N-acetyl derivatives of neomycins B and C. Production series antibiotics in the form of sulfuric acid salts were the initial materials; the latter were converted into a base on resin JRA-400 in OH form, after which acetylation with acetic anhydride in absolute methanol gave N-acetyl derivatives with a yield of 93-96%.

Descriptors :   *Antibiotics, *Neomycins, Chromatographic analysis, Chemical composition, USSR, Translations

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE