Accession Number : AD0780125

Title :   Sequential Immunization of Spider Monkeys with Three Group B. Arboviruses: Yellow Fever, Langat, and Dengue-2.

Descriptive Note : Annual progress rept.,

Corporate Author : YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE

Personal Author(s) : Casals-Ariet,Jordi

Report Date : 01 MAY 1974

Pagination or Media Count : 18

Abstract : Four spider monkeys were sequentially vaccinated at 30-days intervals with yellow fever (17D), a Langat and a dengue type 2 attenuated strains. Four months after the last vaccination these monkeys and 4 controls which had been injected the vaccine substrates only were subcutaneously challenged with Japanese encephalitis virus. As anticipated, none of these animals developed signs of illness; viremia titrations done daily for seven consecutive days after challenge were used as a criterion for protection. No protection was detected as a result of vaccination. (Author)

Descriptors :   *Group B arboviruses, *Vaccines, *Immunization, Yellow fever virus, Dengue, Virus diseases

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE