Accession Number : AD0780848

Title :   Distribution of Progesterone and Its Effect on Human Blood during Storage.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto,Frank ; Wilson,Sarah M.

Report Date : 29 MAR 1974

Pagination or Media Count : 14

Abstract : Erythrocytes, preserved with addition of progesterone to whole blood, maintain higher adenosine triphosphate levels, lower spontaneous lysis, higher osmotic resistance and higher uptake of methylene blue throughout 42 days of storage when compared to red cells preserved without progesterone. The hormone appears to be in steady-state equilibrium between plasma and erythrocytes and the amount in the plasma is almost twice that present in the cells. After repeated saline extractions, about 10% of the total progesterone remains attached to the erythrocytes. Cell populations of low density (young cells) show high specific activity throughout the storage time investigated. (Author)

Descriptors :   *Blood preservation, *Progesterone, Methylene blue, Adenosine phosphates, Blood banks, Blood transfusion, Erythrocytes, Hormones, Osmosis, Biochemistry

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE