Accession Number : AD0780849

Title :   Evaluation of Oral Administration of Adenine to Dogs and Primates.

Descriptive Note : Progress rept.,


Personal Author(s) : Shields,Charles E. ; Ervin,John T. ; Burns,Mark G.

Report Date : 28 MAR 1974

Pagination or Media Count : 13

Abstract : Little change was observed in primates fed 75 mg/kg adenine over the four-week period. Minimal tissue pathology was encountered upon completion of the study. In contrast to earlier studies in which oral feeding of adenine to dogs caused severe symptoms, and even death, the present subjects had very little symptomatic difficulty and some weight loss. Upon autopsy of the dogs, changes in renal tissue were found to support the possible adverse effect of adenine. The adenine presently used here was at least 95-99% pure and the dose of 75 mg/kg was higher than that given in most of the earlier studies, but a less effect was observed. This dose, when related to the 10 mg/kg considered to be the maximum for transfusion therapy, would suggest that a margin of safety does exist for use of adenine as a supplement to improve stored blood preservation. (Modified author abstract)

Descriptors :   *Adenine, *Blood preservation, Blood donors, Purines, Dogs, Primates, Tissues(Biology), Pathology, Toxicity, Lethal dosage, Ingestion(Physiology), Pharmacology, Intestines, Blood transfusion, Bioassay

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE