Accession Number : AD0781418

Title :   Synthesis of 3- and 4-O-beta-D-Galactopyranosyl-L-Rhamnose, and of 3-O-(2-Acetamido-2-Deoxy-beta-D-Glucopyranosyl)-L-Rhamnose, and Their Use in Precipitin Inhibition Studies with Type VII Antipneumococcal Serum,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGICAL SCIENCES

Personal Author(s) : King,Russell R. ; Bishop,Claude T.

Report Date : 27 AUG 1973

Pagination or Media Count : 12

Abstract : Syntheses of 3- and 4-O-beta-D-galactopyranosyl-L-rhamnose and of 3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-rhamnose are described. Comparison of the inhibitory powers of these three disaccharides with those of a selection of other disaccharides on the precipitin reaction between Type VII antipneumococcal horse serum and Type VII pneumococcal polysaccharide or Tamarind A polysaccharide showed that O-D-galactosyl- and O-(2-acetamido-2-deoxy-D-glucosyl)-L-rhamnose groups are important serological determinants in the pneumococcal Type VII polysaccharide. (Author)

Descriptors :   *Serology, *Disaccharides, *Diplococcus pneumoniae, Synthesis(Chemistry), Nuclear magnetic resonance, Molecular structure, Chemical reactions, Inhibitors, Polysaccharides, Bacteria, Precipitation, Antigen Antibody reactions, Immunology, Oxygen heterocyclic compounds, Canada

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE