Accession Number : AD0781501

Title :   The Reversible Effects of Acute Adenine Toxicity in Rats.

Descriptive Note : Final rept.,


Personal Author(s) : Ervin,J. T. ; Greenwood,S. M. ; Shields,C. E. ; Endorf,D. E. ; Levasseur,S. E.

Report Date : 15 APR 1974

Pagination or Media Count : 18

Abstract : From this study in a large population of rats, adenine toxicity to renal tissue was found to be dose-rate related. Average transient weight loss was encountered at all levels; however, recovery by the end of 30 days was complete. It was shown that a dose level of 25 mg/kg body weitht is the only dose level at which no evidence of morphologic renal damage occurs, although a single transient rise in BUN and creatinine values took place. At higher dose levels, below the LD50, a more prolonged transient uremia and renal impairment was a consistent finding. Acute tubular necrosis was encountered initially; however, a complete morphologic recovery was documented by one week in 50 and 100 mg/kg body weight dose levels. Based on information obtained from animal models, adenine in doses less than 25 mg/kg body weight would be reasonable if renal function was normal. (Modified author abstract)

Descriptors :   *Adenine, *Kidneys, Urinary system, Toxicity, Dosage, Pathology, Physiology, Tissues(Biology), Rats, Experimental data, Blood preservation

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE