Accession Number : AD0782238

Title :   Summary Statement of Studies on Tissue Hypoxia and Altered Cerebral Function during Hyperthermia.

Descriptive Note : Final rept. 1 May 63-30 Apr 71,

Corporate Author : RUTGERS - THE STATE UNIV NEW BRUNSWICK N J DEPT OF PHYSIOLOGY

Personal Author(s) : Frankel,Harry M.

Report Date : APR 1974

Pagination or Media Count : 13

Abstract : Studies of cerebral oxygen and cerebral glucose consumption during hyperthermia indicated that at a body temperature of 42C, cerebral oxygen consumption increased and glucose consumption was unchanged compared to control temperature. From these data and earlier data on tissue and cerebral venous blood oxygen, the authors concluded that cerebral hypoxia did not develop before evidence of other physiological failure during hyperthermia. The fact that glucose consumption was not increased at 42C, suggested the possibility of failure in cerebral metabolism as a result of limitation in substrate transport, e.g., glucose, across the blood-brain barrier rather than a limitation in O2 availability.

Descriptors :   *Hyperthermia, *Hypoxia, *Brain, *Stress(Physiology), Tissues(Biology), Cerebrum, Pathology, Lactates, Glucose, Pyruvates, Metabolism, Body temperature, Oxygen, Carbon dioxide

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE