Accession Number : AD0782260

Title :   Immunopathology of Malaria and Other Haemosporidian Infections.

Descriptive Note : Rept. no. 6 (Final) 1966-70,


Personal Author(s) : Cox,Herbert W.

Report Date : 22 JUL 1974

Pagination or Media Count : 11

Abstract : Anemia and nephritis were found to be a disease syndrome associated with a variety of infectious agents, e.g., Plasmodium, Babesia, Haemobartonella, Eperythrozoon, and duck infectious anemia virus. Regardless of the nature of the etiologic agent, the anemia-nephritis syndrome in each infection was related to the same or similar autoimmune-like factors: a cold-active hemagglutinin (CAH0 for trypsinized erythrocytes, and an antigenic globulin, termed serum antigen (SA) along with its antibody (ABSA). The presence of dissociated SA and ABSA in material eluted from blood cells, material extracted from diseased kidneys, and in the urinary wastes of malarious chickens, indicated that soluble complexes of SA and ABSA might have been causal of hemolytic anemia and glomerulonephritis. The association of similar pathologic and immunologic factors in these various infectious diseases indicate that there is a basis for grouping them under the term 'infectious anemias'. (Author)

Descriptors :   *Malaria, *Immunology, *Anemias, *Kidney diseases, *Parasitic diseases, Animals, Infectious diseases, Pathogenesis, Spleen

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE