Accession Number : AD0783481

Title :   Deposition of Ultrafine Aerosols in the Respiratory Tract of Human Volunteers.

Descriptive Note : Special publication, Aug 72-Jun 73,


Personal Author(s) : Shanty,Frank

Report Date : JUN 1974

Pagination or Media Count : 102

Abstract : Techniques were devised for generating and sizing an ultrafine, monodisperse aerosol and the aerosol was used in deposition studies in the respiratory tract of human test subjects. A simple technique was developed for producing and sizing an 0.08 micrometer aerosol tagged with TC99m, a gamma-emitting radioisotope with a half life of 6 hours. The test aerosol was reasonably monodisperse, exhibiting geometric standard deviations in the range of 1.05 to 1.35. Hygroscopic growth of the test aerosol under conditions simulating humidification in the respiratory tract was measured. An apparatus was constructed for use in conducting aerosol breathing studies. The experimental setup would also be suitable for lung scanning studies, including regional deposition studies. Fractional deposition of the test aerosol was measured for both mouth breathing and nasal breathing. (Author)

Descriptors :   *Aerosols, *Respiratory system, Theses, Humans, Radioactive isotopes, Tracer studies, Ultrafines, Medical equipment, Lung, Laboratory equipment

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE