Accession Number : AD0783611

Title :   Mathematical Models for Simulating Physiological Responses to Severe Military Stress: Renal Function Details,

Corporate Author : RAND CORP SANTA MONICA CALIF

Personal Author(s) : Bigelow,J. H. ; DeHaven,J. C. ; Shapley,M. L.

Report Date : JUN 1973

Pagination or Media Count : 61

Abstract : A previous model of the renal function and compartmented whole body, which incorporated actions of antidiuretic hormone on urine flow and composition, is extended to include the influences of additional phenomena, many exogenous to the kidney. These include the intrinsic-osmotic effect of water; details of the body's antidiuretic hormone cycle; gastrointestinal exchanges; changes in glomerular filtration caused by alternation in blood volume and pressure; and resistance to flow across kidney tubular walls. The responses of the model were validated by comparison with responses of actual subjects, as reported in the literature. The model was exposed to and responded correctly to physiological stresses.

Descriptors :   *Stress(Physiology), *Mathematical models, *Response(Biology), Urinary system, Air force, Kidneys, Medical research, Military medicine, Blood pressure, Computerized simulation, Osmosis, Experimental data, Metabolism

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE