Accession Number : AD0783925

Title :   Experimental Use of Antibiotic-Immunodepressants,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Ado,V. A. ; Akimov,V. G. ; Goryanchkina,L. A. ; Podkolzin,A. A. ; Maksimenko,S. F.

Report Date : 22 JUL 1974

Pagination or Media Count : 14

Abstract : The antibiotic-immunodepressants (dactinomycin, bruenomycin, and rubomycin) in the doses used on the guinea pigs and hamsters selected for reproduction of the allergic reactions exhibited an expressed toxic effect. Dactinomycin in doses to 30 micrograms/kg exerted an expressed immunodepressant effect. Bruneomycin in doses of 0.75 mg/kg significantly inhibited the development of allergic contact dermatitis to 2,4-dinitro-chloro-benzene, but did not protect the animals from anaphylactic shock. Rubomycin in doses of 30 mg/kg did not inhibit allergic reactions of the immediate and delayed types.

Descriptors :   *Antibiotics, *Immunology, Toxicology, Pharmacology, Guinea pigs, Experimental data, USSR, Translations, Dosage, Laboratory animals, Hamsters, Allergic diseases

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE