Accession Number : AD0784013

Title :   Effectiveness of Different Methods of Specific Desensitization by Microbial Allergens,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Dashtayants,G. A. ; Sidorenko,Ye. N.

Report Date : 24 JUL 1974

Pagination or Media Count : 13

Abstract : The significance of microbial allergy with bronchial asthma is recognized by many researchers. Several widely accepted methods for sepcific desensitization by microbial antigens are examined. The following types of microbial antigens were employed: 'soluble', which is a supernatant liquid of microbial suspension not containing microbial cells; 'full' antigens which include microbial cells, and the products of their metabolism. The 'full' antigens of all autostrains isolated from sputum, heterovaccines, which are a mixture of antigens on which positive skin reactions were detected on the patient, and also by a combined vaccine, which is a standard mixture of all forms of microorganisms, most frequently sown from the sputum of patients with bronchial asthma. Treatment was carried out subcutaneously and intracutaneously. The conclusions were as follows: The 'soluble' noncellular microbial allergens possess low therapeutic effectiveness considerably inferior to 'full' antigens. The effectiveness of autovaccines, heterovaccines, and a combined vaccine is approximately identical.

Descriptors :   *Allergic diseases, *Respiratory diseases, *Vaccines, Therapy, Desensitizing, Antigens, Microorganisms, Bacteria, USSR, Translations

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE