Accession Number : AD0784404

Title :   Serological Diagnosis of Gonorrhea.

Descriptive Note : Annual rept. no. 1, Sep 73-31 Aug 74,

Corporate Author : MONTANA UNIV MISSOULA DEPT OF MICROBIOLOGY

Personal Author(s) : Rudbach,Jon A. ; Luoma,M. Kay ; Cross,William R.

Report Date : 31 AUG 1974

Pagination or Media Count : 37

Abstract : An antigen has been extracted from T1 phase of Neisseria gonorrhoeae which has been characterized very crudely as a nucleoprotein. Preparations of this antigen were labeled biosynthetically with 14C and used in a radioassay for serodiagnosis of gonorrhea in humans. The results of the assays with this antigen may be summarized as follows: 90% of male and 98% of female sera were correctly diagnosed as positive (combined 93% correct); 32% of male and 82% of female sera were correctly diagnosed as negative (combined 60% correct); 5% of male and 2.5% of female sera could not be assigned positive or negative values. Preliminary results with an 125I labeled gonococcal antigen were similar to those described above. (Author)

Descriptors :   *Serodiagnosis, *Neisseria gonorrhoeae, Experimental data, Infectious diseases, Diagnosis(Medicine), Nucleoproteins, Antigens, Humans, Microbiology, Naval research, Cultures(Biology), Carbon, Iodine, Labeled substances, Radioimmunoassay

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE