Accession Number : AD0784701

Title :   Concerning the Crossed Allergic Reactions Caused by Conjugates of Dinitrophenol with Protein, and Their Specific Inhibition,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Ado,V. A. ; Podkolzin,A. A. ; Goryachkin,L. A.

Report Date : 15 AUG 1974

Pagination or Media Count : 11

Abstract : The sensitization of guinea pigs by conjugates of dinitrophenol+bovine gamma-globulin and dinitrophenol+bovine fibrinogen showed the possibility of developing immediate-type crossed allergic reactions (anaphylactic shock). Intravenous introduction before testing the conjugates to dinitrochlorbenzene (DNCB)-sensitized guinea pigs produced a more intensitive cross inhibition of development of skin-allergic contact reaction (contact dermatitis) than the same intravenous injection of DNCB in TWEEN-80. The depression of dermatitis is expressed (visually and histologically) the less the period between the hyposensitizing introduction of allergen and testing.

Descriptors :   *Anaphylaxis, *Allergic diseases, Immunology, Dermatitis, Sensitizing, Nitrophenols, Proteins, Guinea pigs, Experimental data, Antigens, USSR, Translations

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE