Accession Number : AD0784701
Title : Concerning the Crossed Allergic Reactions Caused by Conjugates of Dinitrophenol with Protein, and Their Specific Inhibition,
Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
Personal Author(s) : Ado,V. A. ; Podkolzin,A. A. ; Goryachkin,L. A.
Report Date : 15 AUG 1974
Pagination or Media Count : 11
Abstract : The sensitization of guinea pigs by conjugates of dinitrophenol+bovine gamma-globulin and dinitrophenol+bovine fibrinogen showed the possibility of developing immediate-type crossed allergic reactions (anaphylactic shock). Intravenous introduction before testing the conjugates to dinitrochlorbenzene (DNCB)-sensitized guinea pigs produced a more intensitive cross inhibition of development of skin-allergic contact reaction (contact dermatitis) than the same intravenous injection of DNCB in TWEEN-80. The depression of dermatitis is expressed (visually and histologically) the less the period between the hyposensitizing introduction of allergen and testing.
Descriptors : *Anaphylaxis, *Allergic diseases, Immunology, Dermatitis, Sensitizing, Nitrophenols, Proteins, Guinea pigs, Experimental data, Antigens, USSR, Translations
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE