Accession Number : AD0784727

Title :   Factors Affecting the Muscle Depolarization Due to 'Conus achatinus' Toxin,

Corporate Author : DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s) : Turner,R. J. ; Freeman,Shirley E.

Report Date : 25 JUN 1973

Pagination or Media Count : 8

Abstract : The action of Conus achatinus toxin on mammalian skeletal muscle has been investigated. Toxin-induced membrane depolarization was wholly or partly antagonized by manganese ions, procaine and a range of sulfhydryl reagents. Toxin-induced twitch blockade was antagonized by dithiothreitol. Possible modes of action of the toxin and the antagonist compounds are discussed. (Author)

Descriptors :   *Toxins and antitoxins, *Musculoskeletal system, Pharmacology, Gastropoda, Australia

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE