Accession Number : AD0784908

Title :   Influence of Altered Gaseous Environments of Lung Metabolism.

Descriptive Note : Final progress rept. 1 Jun 73-31 May 74,


Personal Author(s) : Rhoades,Rodney A.

Report Date : JUL 1974

Pagination or Media Count : 31

Abstract : Studies with isolated perfused rat lungs ventilated for 1.5 hr. at different oxygen tensions indicate that: Lactate production is inversely related to oxygen tension being significantly decreased with hyperoxia and significantly increased with hypoxia. Pyruvate production was not markedly affected with hypoxia. Glucose uptake is stimulated slightly with hypoxia, but the increase is not significant at the 5% level. Both glucose and palmitate utilization assessed by incorporation into total lipids, neutral lipids, phospholipids, PL - fatty acids, PL - glyceride glycerol, and oxidation to 14CO2 was not significantly altered by acute hypoxic stress. Pulmonary pressure showed a significant 31% increase during acute hypoxia; however, the presence of pulmonary edema was minimal. Acute hypoxic stress did not significantly affect lung glycogen content. Exposure to hypoxia for 24 hours, on the other hand, had a profound influence on the lung. Lactate production showed a significant 80% increase with the lactate-pyruvate ratio showing a 40% increase. Pyruvate production also showed a marked increase. Glucose uptake was significantly stimulated with 24 hour hypoxia. Glucose oxidation and incorporation into lung lipids were also significantly increased. (Modified author abstract)

Descriptors :   *Lung, *Hypoxia, *Metabolism, Fatty acids, Lactates, Pyruvates, Glucose, Glycogen, Stress(Physiology), In vitro analysis

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE